Infections in the brain can have serious consequences and are often fatal. The immune defense system works differently here than in the rest of the body. A team of researchers at TWINCORE—Center for Experimental and Clinical Infection Research in Hanover—has now discovered, in collaboration with partners, which signaling pathways play a central role in communication between immune cells in the brain in their defense against viruses. The results have now been published in the Journal of Neuroinflammation.